Research Activities

Research activities

The CALIPER team is a leading contributor to paediatric laboratory medicine and has published over 50 articles in peer reviewed journals.

We continue to establish accurate paediatric reference intervals for all routine and specialized biomarkers of health and disease across several different laboratory testing systems. This ensures laboratories, healthcare professionals, and families have access to robust reference intervals, regardless of the type of equipment used to test children and adolescents.

As the CALIPER project continues to grow and develop, the database will be updated with new tests.

Current Research Focus

Our team is currently focused on studies regarding maternal health, early childhood, COVID-19, and pediatric obesity. If you are interested in learning more, please find more information below or contact us!

Publications

Highlighted Publications

  1. Adeli K, Higgins V, Trajcevski K, White-Al Habeeb N. The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper. Crit Rev Clin Lab Sci. 2017 Sep;54(6):358-413. doi: 10.1080/10408363.2017.1379945.
  2. Adeli K, Higgins V, Trajcevski K, Palmert MR. Important considerations for interpreting biochemical tests in children. BMJ. 2018 May 24;361:k1950. doi: 10.1136/bmj.k1950.
  3. Higgins V, Asgari S, Hamilton JK, Wolska A, Remaley AT, Hartmann B, Holst JJ, Adeli K. Postprandial dyslipidemia, hyperinsulinemia, and impaired gut peptides/bile acids in adolescents with obesity. J Clin Endocrinol Metab. 2020 Apr 1; 105(4):dgz261. doi: 10.1210/clinem/dgz261.
  4. Higgins V, Omidi A, Tahmasebi H, Asgari S, Gordanifar K, Nieuwesteeg M, Adeli K. Marked influence of adiposity on laboratory biomarkers in a healthy cohort of children and adolescents. J Clin Endocrinol Metab. 2020 Apr 1;105(4):dgz161. doi: 10.1210/clinem/dgz161.
  5. Tahmasebi H, Asgari S, Hall A, Higgins V, Chowdhury A, Thompson R, Bohn MK, Macri J, Adeli K. Influence of ethnicity on biochemical markers of health and disease in the CALIPER cohort of healthy children and adolescents. Clin Chem Lab Med. 2020 Mar 26;58(4):605-617. doi: 10.1515/cclm-2019-0876.

Recent Publications

  1. Lam E, Higgins V, Zhang L, Chan MK, Bohn MK, Trajcevski K, Liu P, Adeli K, Nathan PC. Normative values of high-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide in children and adolescents: A study from the CALIPER cohort. J Appl Lab Med. Epub 2020 Sep 30. doi: 10.1093/jalm/jfaa090. [online ahead of print]
  2. Bohn MK, Higgins V, Tahmasebi H, Hall A, Liu E, Adeli K, Abdelhaleem M. Complex biological patterns of hematology parameters in childhood necessitating age- and sex-specific reference intervals for evidence-based clinical interpretation. Int J Lab Hematol. 2020 Dec;42(6):750-760. doi: 10.1111/ijlh.13306.
  3. Thompson S, Bohn MK, Mancini N, Loh TP, Wang CB, Grimmler M, Yuen KY, Mueller R, Koch D, Sethi S, Rawlinson WD, Clementi M, Erasmus R, Leportier M, Kwon GC, Menezes ME, Patru MM, Gramegna M, Singh K, Najjar O, Ferrari M, Lippi G, Adeli K, Horvath A and the IFCC Taskforce on COVID-19. IFCC interim guidelines on biochemical/hematological monitoring of COVID-19 patients. Clin Chem Lab Med. 2020 Oct 7;58(12):2009-2016. doi: 10.1515/cclm-2020-1414.
  4. Bohn MK, Loh TP, Wang CB, Mueller R, Koch D, Sethi S, Rawlinson WD, Clementi M, Erasmus R, Leportier M, Grimmler M, Yuen KY, Mancini N, Kwon GC, Menezes ME, Patru MM, Gramegna M, Singh K, Najjar O, Ferrari M, Horvath A, Lippi G, Adeli K and the IFCC Taskforce on COVID-19. IFCC interim guidelines on serological testing of antibodies against SARS-CoV-2. Clin Chem Lab Med. 2020 Oct 7;58(12):2001-2008. doi: 10.1515/cclm-2020-1413.
  5. Bohn MK, Mancini N, Loh TP, Wang CB, Grimmler M, Gramegna M, Yuen KY, Mueller R, Koch D, Sethi S, Rawlinson WD, Clementi M, Erasmus R, Leportier M, Kwon GC, Menezes ME, Patru MM, Singh K, Ferrari M, Najjar O, Horvath A, Adeli K, Lippi G and the IFCC Taskforce on COVID-19. IFCC interim guidelines on molecular testing of SARS-CoV-2 infection. Clin Chem Lab Med. 2020 Oct 7;58(12):1993-2000. doi: 10.1515/cclm-2020-1412.
  6. Bohn MK, Hall A, Sepiashvili L, Jung B, Steele S, Adeli K. Pathophysiology of COVID-19: Mechanisms Underlying Disease Severity Progression. Physiology (Bethesda). 2020 Sep 1;35(5):288-301. doi: 10.1152/physiol.00019.2020.
  7. Higgins V, Tahmasebi H, Bohn MK, Hall A, Adeli K. CALIPER Hematology Reference Standards (I). Am J Clin Pathol. 2020 Aug 5;154(3):330-341. doi: 10.1093/ajcp/aqaa059.
  8. Higgins V, Tahmasebi H, Bohn MK, Hall A, Adeli K. CALIPER Hematology Reference Standards (II). Am J Clin Pathol. 2020 Aug 5;154(3):342-352. doi: 10.1093/ajcp/aqaa057.
  9. Adeli K. Critical role of laboratory medicine in the global response to the COVID-19 pandemic. Clin Chem Lab Med. 2020 Jun 25;58(7):1019-1020. doi: 10.1515/cclm-2020-0742.
  10. Bohn MK, Lippi G, Horvath A, Sethi S, Koch D, Ferrari M, Wang CB, Mancini N, Steele S, Adeli K. Molecular, serological, and biochemical diagnosis and monitoring of COVID-19: IFCC taskforce evaluation and latest evidence. Clin Chem Lab Med. 2020 Jun 25;58(7):1037-1052. doi: 10.1515/cclm-2020-0722.
  11. Higgins V, Adeli K. Postprandial dyslipidemia in insulin resistant states in adolescent populations. J Biomed Res. 2020 Jan 30;34(5):328-342. doi: 10.7555/JBR.34.20190094.
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